| MPC Soccer vs. Yuba College (Away) | 08/31/2021 4:00 PM | |
| MPC Volleyball Classic (Home) | 09/03/2021 | |
| MPC Soccer vs. Clovis Community College (Away) | 09/03/2021 4:00 PM | |
| MPC Football vs. Los Medanos College (Away) | 09/04/2021 1:00 PM | |
| MPC Soccer vs. Consumnes River College (Away) | 09/05/2021 12:00 PM - 2:00 PM | |
| MPC Soccer vs. Allan Hancock (Home) | 09/07/2021 6:30 PM | |
| MPC Volleyball vs. Reedley College (Home) | 09/08/2021 5:00 PM | |
| MPC Volleyball Classic (Home) | 09/10/2021 | |
| MPC Soccer vs. West Hills College (Home) | 09/10/2021 4:00 PM | |
| MPC Football vs. Yuba College (Home) | 09/11/2021 1:00 PM | |
| MPC Cross Country vs. Kim Duyst Twilight XC Invitational (Away) | 09/11/2021 8:30 PM | |
| MPC Volleyball vs. Cuesta/Santa Barbara City (Away) | 09/15/2021 | |
| MPC Soccer vs. College of the Sequoias (Away) | 09/17/2021 3:30 PM | |
| MPC Football vs. Feather River College (Away) | 09/18/2021 1:00 PM | |
| MPC Soccer vs. Yuba College (Home) | 09/21/2021 4:00 PM | |
| MPC Football vs. Contra Costa College (Home) | 09/25/2021 6:00 PM | |
| MPC Soccer vs. Merced College (Away) | 09/27/2021 4:00 PM | |
| MPC Volleyball vs. West Valley College (Home) | 09/29/2021 6:30 PM | |
| MPC Cross Country vs. Toro Park Invitational (Away) | 10/01/2021 3:30 PM | |
| MPC Soccer vs. West Valley College (Away) | 10/01/2021 4:00 PM | |
| MPC Volleyball vs. De Anza College (Away) | 10/01/2021 6:30 PM | |
| MPC Football vs. Foothill College (Away) | 10/02/2021 1:00 PM | |
| MPC Soccer vs. Evergreen College (Away) | 10/05/2021 4:00 PM | |
| MPC Volleyball vs. Gavilan College (Home) | 10/06/2021 6:30 PM | |
| MPC Soccer vs. Ohlone College (Away) | 10/08/2021 4:00 PM | |
| MPC Football vs. Deanza College (Home) | 10/09/2021 6:00 PM | |
| MPC Soccer vs. Cabrillo College (Home) | 10/12/2021 6:30 PM | |
| MPC Women's Basketball vs. Cabrillo College (Home) | 10/14/2021 5:30 PM | |
| MPC Soccer vs. Chabot College (Home) | 10/15/2021 4:00 PM | |
| MPC Soccer vs. CCSF (Home) | 10/22/2021 4:00 PM | |
| MPC Football vs. Merced College (Away) | 10/23/2021 1:00 PM | |
| MPC Women's Basketball vs. Allan Hancock (Home) | 10/23/2021 2:00 PM | |
| MPC Soccer vs. Foothill College (Away) | 10/26/2021 4:00 PM | |
| MPC Cross Country vs. Coast Conference Championships (Away) | 10/27/2021 2:30 PM | |
| MPC Soccer vs. Skyline (Home) | 10/29/2021 2:00 PM | |
| MPC Football vs. Gavilan College (Home) | 10/30/2021 6:00 PM | |
| MPC Soccer vs. Cañada College (Away) | 11/02/2021 4:00 PM | |
| MPC Women's Basketball vs. San Mateo (Away) | 11/02/2021 5:00 PM | |
| MPC Men's Basketball (Away) SJCC Tip-Off Tourney | - | |
| MPC Women's Basketball vs. Mission Tourney (Away) | - | |
| MPC Cross Country vs. NorCal Regional Championships (Away) | 11/05/2021 2:00 PM | |
| MPC Soccer vs. DeAnza College (Away) | 11/05/2021 4:00 PM | |
| MPC Football vs. Hartnell College (Away) | 11/06/2021 6:00 PM | |
| MPC Soccer vs. Las Positas College (Home) | 11/09/2021 3:00 PM | |
| MPC Women's Basketball vs. Skyline College (Away) | 11/09/2021 5:00 PM | |
| MPC Men's Basketball vs. Foothill College (Away) | 11/10/2021 6:00 PM | |
| MPC Women's Basketball vs. Shasta College (Home) | 11/11/2021 5:00 PM | |
| MPC Men's Basketball vs. Chabot College (Home) | 11/12/2021 3:00 PM | |
| MPC Soccer vs. Hartnell College (Home) | 11/12/2021 6:30 PM | |
| MPC Football vs San Jose City College (Home) | 11/13/2021 6:00 PM | |
| MPC Women's Basketball vs. Marin College (Away) | 11/16/2021 5:30 PM | |
| MPC Men's Basketball vs. Lemoore College (Home) | 11/19/2021 5:00 PM | |
| MPC Women's Basketball vs. Los Medanos College (Away) | 11/19/2021 5:30 PM | |
| MPC Cross Country vs. CCCAA State Meet (Away) | 11/20/2021 10:00 AM | |
| MPC Women's Basketball vs. Foothill College (Home) | 11/23/2021 5:00 PM | |
| MPC Men's Basketball vs. Ohlone College (Away) | 11/23/2021 5:00 PM | |
| MPC Men's Basketball vs. Monterey Bay Classic (Home) | - | |
| MPC Women's Basketball vs. Ohlone College (Away) | 12/02/2021 5:00 PM | |
| MPC Women's Basketball vs. Merritt College (Home) | 12/07/2021 5:30 PM | |
| MPC Men's Basketball vs. Modesto College Tourney (Away) | - | |
| MPC Men's Basketball vs. Porterville College (Home) | 12/15/2021 5:00 PM | |
| MPC Women's Basketball vs. Foothill College (Away) | 12/15/2021 5:00 PM | |
| MPC Women's Basketball vs. College of the Siskiyous (Home) | 12/17/2021 5:00 PM | |
| MPC Women's Basketball vs. Feather River College (Home) | 12/21/2021 3:00 PM | |
| MPC Women's Basketball vs. Fresno City College (Home) | 12/22/2021 12:00 PM | |
| MPC Men's Basketball vs. Contra Costa College (Away) | 12/29/2021 6:00 PM | |
| MPC Women's Basketball vs. Reedley College (Home) | 01/03/2022 3:00 PM | |
| MPC Men's Basketball vs. Gavilan College (Away) | 01/05/2022 7:00 PM | |
| MPC Women's Basketball vs. San Jose (Away) | 01/12/2022 5:00 PM | |
| MPC Men's Basketball vs. San José City College (Away) | 01/12/2022 7:00 PM | |
| MPC Women's Basketball vs. Mission College (Home) | 01/19/2022 5:00 PM | |
| MPC Men's Basketball vs. West Valley College (Home) | 01/19/2022 7:00 PM | |
| MPC Women's Basketball vs. Cabrillo College (Away) | 01/21/2022 5:00 PM | |
| MPC Men's Basketball vs. Cabrillo College (Away) | 01/21/2022 7:00 PM | |
| MPC Men's Basketball vs. Hartnell College (Home) | 01/24/2022 5:00 PM | |
